ACC Analytical Standard

PHAS-117

ACC Analytical Standard

CAS Number: 22059-21-8. Empirical Formula: C4H7NO2.

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks 3H-glycine binding to rat forebrain membranes (IC50 = 38 nM).
An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

Crystalline solid

≥ 98% by TLC

Following reconstitution, aliquot and freeze (-20 centigrade). Stock solutions are stable for up to 1 month at -20 centigrade.

1-Aminocyclopropane-1-carboxylic Acid; ACPC