Metabolomics is a powerful approach to identification and quantification of the small molecule metabolites (the metabolome) present in a biological system (cell, tissue, organ, biological fluid, or organism) at a specific point of time. The metabolome is dynamic, changing from second to second; therefore, metabolomics allows the study of dynamic metabolic alterations of a living system in response to genetic modifications or physiopathological stimuli.
Lifeasible is a worldwide leader in ultra-trace analysis of small-molecule entities. We provide metabolomics analysis for both plant and animal using the latest technologies and novel methods. Our metabolomics analysis services are featured with:
- One-stop services from sample collection, sample preparation, data acquisition to data analysis and interpretation (Figure 1).
Figure 1. The workflow of a metabolomics study.
Figure 2. Untargeted versus targeted metabolomics studies (Schrimpe-Rutledge et al., 2016).
- State-of-the-art technologies:
- Liquid chromatography-mass spectrometry (LC-MS): LC-MS provides an excellent platform for the analysis of redox metabolites, coenzymes, nucleotides, and lipids.
- Gas chromatography-mass spectrometry (GC-MS): GC-MS is especially useful for identification and quantification of small and volatile molecules. It has proven to be highly reliable for the analysis of amino acids, TCA cycle and related metabolites, other organic acids, free fatty acids and sterols, glycolytic intermediates, carbohydrates, as well as purine and pyrimidine bases.
- Nuclear magnetic resonance (NMR): NMR depends on specific magnetic properties of certain atomic nuclei. NMR spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics, crystals as well as non-crystalline materials. At Lifeasible, both 1H-NMR and 13C-NMR spectroscopies are available.
- Short turnaround time.
- Competitive price.
- High accuracy, specificity, and sensitivity.
Our skilled scientists and experts are devoted to the exploration and optimization of protocol for metabolomics analysis. We proudly provide tailored solutions to meet the diverse requirements of our customers and guarantee the success of each project. Welcome to contact us for further information.
- Schrimpe-Rutledge A. C.; et al. Untargeted metabolomics strategies – Challenges and emerging directions. J Am Soc Mass Spectrom. 2016, 27(12): 1897–1905.
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