Photosynthetic Autotrophs as the Production Platform

The photosynthetic, autotrophic lifestyle of plants and algae makes them ideal platform organisms for the sustainable production of biomolecules. Based on advanced technologies in synthetic biology, Lifeasible continues to provide effective solutions to problems at the forefront of synthetic biology development in agriculture, and our solutions related to the use of photosynthetic autotrophic systems as bio-platforms are now widely used in the production of compounds with high economic value, such as vaccines, antibodies, biopharmaceuticals, and biofuels.

Photoautotrophic systems as bio-production platforms have been widely used in the production of high-value compounds.

Due to the low cost, high scalable biomass yield, and absence of endotoxin synthesis, photoautotrophic organisms are well suited for systems for large-scale production of immunotherapeutic, biopharmaceuticals, and biofuels. In addition, natural post-translational modification facilities can be further engineered. Efficient green cell factories, can be used to produce drugs and cosmetics. Aquatic phototrophic organisms, such as some algae, are also relevant for biofuel production. In addition to phototrophic organisms, such as artificial leaves and synthetic photosynthetic cells, fully synthetic or biohybrid systems can also use solar energy as a driving force. We are dedicated to the field of synthetic biology in agriculture and provide effective solutions for the development of synthetic biology in agriculture.

• Scale production of artemisinin in biomass crops
• Improved saccharification efficiency
• Synthetic or biomixing systems
• Using moss to produce vaccines and cosmetics

Genetic engineering technologies for supporting photosynthetic autotrophic production platforms

• TALEN

We offer TALEN technology, which allows the construction of recombinant nucleases targeting any specific nucleic acid target sequence, interrupting the target gene DNA at a specific site and thus performing DNA manipulation. TALEN technology provides an important technological foundation for synthetic biology in agriculture.

• CRISPR/Cas system-mediated gene editing technology

We can edit the target by artificially designed gRNA (guide RNA) to identify the target genomic sequence and guide Cas9 protease to efficiently cut the DNA double-strand, forming a double-strand break, and repairing it after damage will cause gene knockout or knock-in, etc.

• Antisense gene technology

Antisense technology is widely used in agricultural synthetic biology research. Through antisense technology, we can breed photoautotrophs with special functions that can produce higher economic value products through targeted mutations of genes. The antisense technology we offer will play an important role in agricultural development.

Our service advantages

Lifeasible uses multidimensional synthetic biology techniques based on photosynthetic chassis to simulate and reshape natural pathways to achieve light-driven synthesis of a variety of high-value natural products. Meanwhile, we develop new strategies for converting and generating natural products, forming new technologies that can be industrialized and laying the foundation for the overall efficiency and economy of biorefineries. In addition, we develop a series of market-oriented biobased products, including active photosynthetic microbial pharmaceuticals and cosmetics, based on the concept of synthetic biology and functional customization of photosynthetic microbial cyanobacteria. If you are interested in us, please feel free to contact us.