Product Name
Angoline hydrochloride
Description
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
Structural Formula
Angoline hydrochloride
Source
Plants >Papaveraceae > Macleaya cordata(Willd.) R. Br.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
IC50 & Target
Human Endogenous Metabolite
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC.[H]Cl
In Vitro
Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively.Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3. Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation.
Datasheet 