Product Name
Nicotinamide riboside chloride
Description
Nicotinamide riboside chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
Structural Formula
Nicotinamide riboside chloride
Solubility
H2O : 125 mg/mL(430.00 mM;Need ultrasonic) DMSO : 50 mg/mL(172.00 mM;Need ultrasonic).
Storage
4℃, sealed storage, away from moisture and light
IC50 & Target
P2X7 Receptor
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O.[Cl-]
In Vivo
Chronic Nicotinamide riboside Chloride supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner.
In Vitro
Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2. Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM. Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.
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