Synonyms
Norharman; β-Carboline
Description
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
Structural Formula
Norharmane
Solubility
DMSO : 11 mg/mL(65.40 mM;Need ultrasonic) H2O : (insoluble)
IC50 & Target
CXCR2 Human Endogenous Metabolite
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
N1C2=C(C=CC=C2)C2=C1C=NC=C2
In Vivo
Norharmane (0-10 mg/kg, IP, once) shows an anxiety- and antidepressant-like behavior, and decreased locomotor activity.
In Vitro
Norharmane attenuates quinolinic acid formation by interferon-gamma-stimulated monocytes THP-1 cells and attenuates L-kynurenine formation, with IC50 values of 51 μM and 43 μM, respectively. Norharmane has the potential for use as an antibiotic adjuvant to enhance the efficacy of conventional antibiotics to reduce pathogenic bacterial infections.
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