Description
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties.Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
Structural Formula
Aloperine
Solubility
DMSO : 5.56 mg/mL(23.93 mM;ultrasonic and warming and heat to 60°C)
Source
Plants >Leguminosae > Sophora alopecuroidesL
Storage
4℃, sealed storage, away from moisture
IC50 & Target
Microbial Metabolite
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
[H][C@]1(C2)[C@](CCCC3)([H])N3C[C@]2([H])[C@@]4([H])C(CCCN4)=C1
In Vitro
Aloperine (1-20 μM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively.Aloperine (1-20 μM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells.Aloperine (20-100 μM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells.
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Datasheet 