Product Name
(+)-Sparteine sulfate pentahydrate
Synonyms
(+)-Lupinidine sulfate pentahydrate
Description
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.
Structural Formula
(+)-Sparteine sulfate pentahydrate
Solubility
DMSO : 33.33 mg/mL(78.88 mM;Need ultrasonic)
Source
Plants >other families
Storage
4℃, sealed storage, away from moisture
IC50 & Target
5-HT1A Receptor
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
[H][C@]12CCCCN1C[C@H]3C[C@@H]2CN4CCCC[C@@]34[H].O=S(O)(O)=O.O.O.O.O.O
In Vitro
(+)-Sparteine (2 μM) (sulfate pentahydrate) reduces the ACh-induced current caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials of -50 mV to +30 mV, whereas its blocking effect increased at more negative membrane potentials. (+)-sparteine (5 μM and 10 μM) (sulfate pentahydrate) reduces the amplitude of the excitatory postsynaptic currents (EPSC) and the time constant of the EPSC decay.
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Datasheet 