Description
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
Solubility
Ethanol : 20 mg/mL(48.59 mM;Need ultrasonic) DMSO : 10 mg/mL(24.29 mM;ultrasonic and warming and heat to 80°C)
Source
Plants >Liliaceae > Veratrum nigrumLinn.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
CC1=C2[C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])C2)([H])CC[C@@]15[C@@H]([C@@]6([H])[C@](C[C@H](C)CN6)([H])O5)C
In Vivo
Cyclopamine causes durable regression of xenograft tumors. Cyclopamine (1.2 mg) treatment blocks tumour formation of human pancreatic adenocarcinoma cells after transplantation into nude mice.
In Vitro
Treatment with small molecule Hh inhibitors such as HhAntag and the natural product Cyclopamine, both binding to Smo, induces tumor remission in a genetic mouse model of medulloblastoma. Cyclopamine is a Hedgehog (Hh) pathway antagonist. Cyclopamine suppresses cell growth. Cyclopamine (3 μM) suppression of Hh pathway activity and growth in digestive tract tumour cell lines correlates with expression of PTCHmRNA.
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Datasheet 