Exosomes are the latest buzzword across the fashion and beauty industries, promising to fight hair loss and improve skin health. On January 26, 2024, ELLE published an article online titled "Everything You Need to Know About Exosomes: How Exosomes Can Be Used in Skin Care, Hair Loss, and Overall Aesthetics."
Exosomes are an important subtype of extracellular vesicles (ECVs), which are tiny nano-sized vesicles secreted by cells and are found in blood, lymph and other body fluids. These tiny vesicles carry rich biological information molecules, including proteins, RNA and DNA fragments. They are like "messengers" between cells, responsible for transmitting information and regulating communication and interactions between cells.
Exosomes have shown numerous potential clinical applications, including stem cell maintenance and plasticity, biomarkers, adjuvants for chemotherapy and drug delivery, and wound healing supplements that promote angiogenesis. Given their broad regenerative potential and cell-free properties, they are increasingly used in the cosmetic field.
As the largest organ of the human body, skin is responsible for multiple functions such as protection, regulating body temperature, and sensing external stimuli. However, with the increase of age and the effect of environmental factors, the skin gradually appears aging, sagging, wrinkles and other phenomena. The emergence of exosomes provides new possibilities for improving skin health.
The mechanism by which exosomes promote skin cell regeneration mainly involves the bioactive molecules they carry and their key role in intercellular communication. Here’s how exosomes promote skin cell regeneration:
Transmission of growth factors and cytokines: Exosomes are rich in growth factors (such as epidermal growth factor, platelet-derived growth factor, etc.) and cytokines. When exosomes are absorbed by skin cells, these growth factors and cytokines can be released and act on the recipient cells, stimulating their proliferation and differentiation. This process helps promote skin cell regeneration and repair.
Regulate gene expression: microRNA (miRNA) and other non-coding RNA in exosomes can enter recipient cells and regulate their gene expression. These RNA molecules can affect the proliferation, differentiation and function of skin cells by inhibiting or promoting the expression of specific genes. This regulation of gene expression helps skin cells adapt to stressful conditions such as injury or aging and promotes regeneration processes.
Promote angiogenesis: During the repair process of skin damage, the formation of new blood vessels is critical to provide oxygen and nutrients and remove waste. Exosomes can stimulate the proliferation and migration of vascular endothelial cells and promote angiogenesis. This process not only helps speed wound healing but also provides essential support for skin cell regeneration.
Modulate immune response: Skin damage is often accompanied by an inflammatory response, and an excessive inflammatory response may hinder the regeneration of skin cells. Exosomes can regulate the activity of immune cells and inhibit excessive inflammatory responses, thereby creating a microenvironment conducive to skin cell regeneration.
Activation of signaling pathways: Certain components in exosomes can activate signaling pathways in recipient cells, such as PI3K/Akt, MAPK/ERK, etc. Activation of these signaling pathways helps promote the proliferation, migration, and differentiation of skin cells, thus accelerating the skin regeneration process.
Hair loss is a problem that plagues more and more people, and exosomes have also shown great potential in treating hair loss. Exosomes can promote blood circulation in the scalp and increase the supply of nutrients to hair follicles, thereby effectively combating hair loss. In addition, they can also regulate the microecological environment of the scalp, inhibit the growth of harmful bacteria, and provide a good environment for hair growth.
| Cat# | Product Name | Size of Exosome Purified | Time to Complete 10 Purifications |
| PE001 | Plasma/Serum Exosome Purification Kit | 40 nm-150 nm | 15-30 minutes |
| PE002 | Urine Exosome Purification Kit | 40 nm-150 nm | 15-30 minutes |
| PE003 | Cell Culture Media Exosome Purification Kits | 40 nm-150 nm | 30-45 minutes |
| PE004 | Saliva Exosome Purification Kit | 40 nm-150 nm | 15-30 minutes |
| PE005 | Plasma/Serum Exosome Purification and RNA Isolation Mini Kit | 40 nm-150 nm | 35-40 minutes |
| PE006 | Plasma/Serum Exosome Purification and RNA Isolation Midi Kit | 40 nm-150 nm | 35-40 minutes |
| PE007 | Plasma/Serum Exosome Purification and RNA Isolation Maxi Kit | 40 nm-150 nm | 35-40 minutes |
| PE008 | Urine Exosome Purification and RNA Isolation Mini Kit | 40 nm-150 nm | 35-40 minutes |
| PE009 | Urine Exosome Purification and RNA Isolation Midi Kit | 40 nm-150 nm | 35-40 minutes |
| PE010 | Urine Exosome Purification and RNA Isolation Maxi Kit | 40 nm-150 nm | 35-40 minutes |
As an emerging skin care ingredient, exosomes are gradually entering people's field of vision. They bring new hope for skin health with their unique mechanisms and multiple effects. From repair and regeneration, anti-aging, to hair loss treatment, exosomes have shown a wide range of application prospects.
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