Liposome Size Analysis

Liposomes are bilayer vesicles made of phospholipids derived from natural or artificial materials. The size of liposomes is an important parameter affecting their encapsulation of small molecule loadings and plays an important role in the functioning of small molecules. In addition to this role, the particle size also determines the solution stability of the liposomes. This is because testing the size of liposomes ensures that they function properly and that the synthesized liposomes encapsulating small molecules are of uniform size.

About Dynamic Light Scattering for Liposome Sizing

Dynamic light scattering (DLS) is used to characterize the size of proteins, macromolecules, micelles, sugars, and nanoparticles. If the system is monodispersed, the average effective diameter of the particles can be found. This measurement depends on the core of the particles, the surface structure, the concentration of the particles, and the type of ions in the medium. DLS can also be used for stability studies by measuring the particle size distribution at different times to show the tendency of the particles to agglomerate and sink over time. As particles agglomerate and sink, more particles with larger particle sizes become available. Similarly, DLS can be used to analyze the effect of temperature on stability.

Our Services

Lifeasible performs size measurements by dynamic light scattering on liposome formulations. The time series showed that the mean particle radius remained stable for 15 hours at 25 °C. The temperature series showed a moderate but constant increase in particle size as the temperature increased above 25 °C. The high degree of precision and reproducibility observed suggests that our dynamic light scattering technique can be well used to study liposome size and stability. Our experimental team can help our customers to analyze liposome size by the dynamic light scattering technique quickly. You can send your product to us, and we will get back to you soon with the results.

Services Content

• Liposome sizing (including custom liposome sizing)
• We can provide solutions for liposome testing
• We can provide data results for liposome testing
• We can provide raw data such as liposome test protocols, instrument parameters, etc.

Service Process

• Contact us to select the required service.
• Sign the agreement and send the samples.
• Design the experiment and perform it.
• Return data reports and results.

Our Advantages

• Lifeasible guarantees our global customers unparalleled service for liposomes.
• Fully integrated liposome solution development.
• Long-standing expertise in liposome size characterization to support liposome development and liposome customization.
• Integrated advanced equipment for high volume, fast turnaround, and package development, among other special services.
• Development of in-house generic methods for various technologies without developing methods from scratch.

If you are interested in our services, or if the service you want is not listed, please feel free to contact us, and we will get back to you as soon as possible.