Mechanism Analysis of Nematode Regulating Host Defense Response

During the interaction between nematodes and plant hosts, functional factors are secreted to regulate the host defense response, which induces the accumulation of host defense products. Eventually, they lead to host death due to excessive defense. Functional factors of plant nematodes mainly include venom allergen proteins (VAPs), thaumatin-like proteins (TLPs), cysteine protease inhibitors (CPIs), and other functional factors that interact with the host.

Lifeasible provides a range of services to our customers worldwide, including venom allergenic proteins, thaumatin-like proteins, cysteine protease inhibitors, and others. With extensive experience and expertise in plant science, we are committed to providing you with timely and high-quality deliverables.

Regulating Host Defense Response by Venom Allergen Proteins

• In the process of interaction with the host, the allergenic protein of nematode venom may be involved in the signaling cascade of protease to regulate the host defense response. The intercellular protease signaling cascade can regulate plant local and systemic defense against pathogens by signaling through the proteolytic process of substrates and activating downstream reactions.

Fig.1 Relative expression levels of RsVAP in different life stages of plant nematodes.

• Lifeasible helps analyze the downstream reactions of venom-like allergenic proteins, such as tomato papain-like cysteine proteases, cell wall degrading enzymes, and others, which induce significant changes in host defense-related genes and inhibit plant immune response. We also analyze the expression of related genes and their effects on the activity, mobility, reproductive rate, and pathogenicity of nematodes.

Regulating Host Defense Response by TLPs and CPIs

• During the interaction between plant nematodes and their hosts, nematodes secrete analog factors to interfere with plant signaling pathways and mediate plant cell development. Nematode thaumatin-like proteins and cysteine protease inhibitors may interfere with host defense response through simulation.
• We provide analysis services for the peptide chains secreted by nematodes, such as CLE, TLPs, and CPIs, which are highly homologous to plants, interfere with host cell proliferation and differentiation, causing the host to continuously produce giant cells and provide food for nematodes.
• We also analyze genes related to functional factors in nematodes, such as TLP1, TLP2, and CPI, and study their relationships with plant hosts. In addition, we help analyze promoters that regulate functional factors such as TLPs and CPIs, including regulatory regions, specific expressions, elements, and activators.

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